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Many people over the years have asked me about why vitamin B12 is so important for our health and what vitamin B12 actually does in the human body. Vitamin B12 is involved in numerous methylation reactions throughout the body and in a vitamin B12 deficiency, these reactions can become compromised.

Vitamin B12 is involved in the production of our genetic code (DNA and RNA), activation of folate, production of red blood cells, keeping homocysteine appropriately low in our body, the production of certain cell membrane components, the production of certain neurotransmitters (including serotonin, melatonin, epinephrine, and dopamine), important reactions involving energy production, and nervous system function. The bottom line is that vitamin B12 is vitally important for a number of life-sustaining activities in our body and should not be overlooked when considering one’s overall health.

Check out this video for more details:

The information in this video builds on a video I did several months ago on the vitamin B12 – folate connection. If you're interested in taking your knowledge to the next level.........

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This pathway is a little biochemically-intense, so I encourage you to watch the video first and then read the text below for clarification.

Vitamin B12 converts homocysteine to methionine by transferring methyl groups from 5-methyl tetrahydrofolate to homocysteine.

In a vitamin B12 deficiency, we often see elevated homocysteine levels, because vitamin B12 is not available to transform homocysteine into methionine. So, homocysteine levels increase.

In a vitamin B12 deficiency we can also see large red blood cells, referred to as macrocytic anemia, because vitamin B12 is not available to convert 5-methyl tetrahydrofolate back into folate. This is called the "methyl folate trap", where folate is "trapped" in the form of 5-methyl tetrahydrofolate. Folate is used to create red blood cells and DNA, and when there isn't enough folate available, red blood cells do not fully mature and stay large. On a lower folate diet, such as with many versions of the standard western diet, we tend to see this situation.

However, when someone with a vitamin B12 deficiency eats a higher folate diet, such as on a plant-based diet, there is a constant supply of folate to create red blood cells and DNA, so red blood cells may appear normal in size. This is how folate can mask a vitamin B12 deficiency. In other words, one needs look beyond the size of red blood cells when testing for vitamin B12 deficiency, and employ other reliable vitamin B12 tests. Accurate vitamin B12 testing by a knowledgeable, licensed clinician is essential for determining one's vitamin B12 status.

If you're interested in taking your knowledge to the next level.........

We cover this topic and so much more in our online Mastering Raw Food Nutrition and Educator Course. For more class details, click here.

One of the best ways to keep in touch with us is to join our email list. We send out monthly newsletters, notifications of our speaking engagements, and more: